| First Author | Ben Lagha N | Year | 2002 |
| Journal | Connect Tissue Res | Volume | 43 |
| Issue | 2-3 | Pages | 515-9 |
| PubMed ID | 12489207 | Mgi Jnum | J:103316 |
| Mgi Id | MGI:3609130 | Citation | Ben Lagha N, et al. (2002) Bone formation in the context of growth retardation induced by hIGFBP-1 overexpression in transgenic mice. Connect Tissue Res 43(2-3):515-9 |
| abstractText | In humans, intrauterine growth retardation (hIUGR) is correlated with an overexpression of insulin-like growth factor binding protein 1 (IGFBP-1). The affected children also present a delay in bone mineralization. In this study, transgenic 12-day-old mutant mice overexpressing human IGFBP-1 hepatospecifically showed a severe growth retardation. Alcian blue and alizarin red S staining of the skeleton revealed mineralization defects at the posterior level of the skull (delayed suture closure) and in appendicular and axial skeleton. Furthermore, microradiographic analysis showed a reduced bone density in the same areas. Thus, overexpressing of hIGFBP-1 demonstrates early postnatal life growth retardation and a delay in mineralization in transgenic mutant mice. These data show the involvement of the IGF/IGFBP system and more particularly IGFBP-1 in the biomineralization process. |
