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Publication : The sequence of a cDNA clone coding for a novel kallikrein from mouse submaxillary gland.

First Author  Fahnestock M Year  1986
Journal  Nucleic Acids Res Volume  14
Issue  12 Pages  4823-35
PubMed ID  3636812 Mgi Jnum  J:8334
Mgi Id  MGI:56802 Doi  10.1093/nar/14.12.4823
Citation  Fahnestock M, et al. (1986) The sequence of a cDNA clone coding for a novel kallikrein from mouse submaxillary gland. Nucleic Acids Res 14(12):4823-35
abstractText  Mouse submaxillary gland contains many proteolytic enzymes, the most widely studied of which are the kallikreins. This gland also contains high levels of nerve growth factor (NGF), which is isolated as a complex of three subunits, alpha, beta, and gamma. We report here the cloning and sequence analysis of a novel kallikrein from mouse submaxillary gland. Antibodies directed against the alpha subunit precipitate the product of this clone, but do not precipitate the homologous gamma subunit. This new kallikrein is therefore closely related to alpha NGF, yet in contrast to the alpha subunit, its sequence suggests it has proteolytic activity.
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