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Publication : Tracheal mucociliary transport in laboratory mice: evidence for genetic polymorphism.

First Author  Brownstein DG Year  1987
Journal  Exp Lung Res Volume  13
Issue  2 Pages  185-91
PubMed ID  3665851 Mgi Jnum  J:8870
Mgi Id  MGI:57335 Doi  10.3109/01902148709064317
Citation  Brownstein DG (1987) Tracheal mucociliary transport in laboratory mice: evidence for genetic polymorphism. Exp Lung Res 13(2):185-91
abstractText  Mean tracheal transport velocities of inhaled 3 mu coumarin-bound monodisperse latex spheres, measured by epi-fluorescence through the intact trachea of anesthetized mice, were 2.29 +/- 0.52 mm/min for C57BL/6J, 0.40 +/- 0.42 mm/min for DBA/2J mice and 1.47 +/- 0.87 mm/min for (C57BL/6J X DBA/2J) F1 mice. A nonparametric analysis of the observed proportions of mice expressing parental phenotypes in second filial, two first backcross and one second backcross generations confirmed the polymorphism to be genetically determined and consistent with a single-locus mode of inheritance.
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