| First Author | Qiao Y | Year | 2016 |
| Journal | Biochem Biophys Res Commun | Volume | 477 |
| Issue | 4 | Pages | 541-547 |
| PubMed ID | 27346130 | Mgi Jnum | J:238524 |
| Mgi Id | MGI:5822972 | Doi | 10.1016/j.bbrc.2016.06.051 |
| Citation | Qiao Y, et al. (2016) miR-483-3p regulates hyperglycaemia-induced cardiomyocyte apoptosis in transgenic mice. Biochem Biophys Res Commun 477(4):541-7 |
| abstractText | Diabetic cardiomyopathy represents severe heart complications, and is the leading cause of morbidity and mortality among patients with diabetes. Although a few microRNAs (miRNAs) have been implicated in diabetes-related complications, a functional association between miRNAs and cardiac dysfunction in diabetic cardiomyopathy remains to be demonstrated. Our results show that miR-483-3p is upregulated in streptozotocin-induced diabetic mice, and cultured cardiomyocytes mimicking hyperglycemia. Overexpressing miR-483-3p in transgenic mice with diabetes mellitus (DM) exacerbated cardiomyocyte apoptosis by transcriptionally repressing insulin growth factor 1 (IGF1). Therefore, we have uncovered a novel signaling pathway, involving miR-483-3p-IGF1, that promotes myocardial cell apoptosis under high blood-glucose condition. Further, our study indicates that miR-483-3p could be a potential therapeutic target for managing diabetes-associated heart complications. |
