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Publication : Age-related effects of NMDA-stimulated concomitant release of nitric oxide and glutamate in cortical slices prepared from DBA/2 mice.

First Author  Rowley HL Year  1993
Journal  Brain Res Volume  613
Issue  1 Pages  49-53
PubMed ID  8102309 Mgi Jnum  J:13288
Mgi Id  MGI:61491 Citation  Rowley HL, et al. (1993) Age-related effects of NMDA-stimulated concomitant release of nitric oxide and glutamate in cortical slices prepared from DBA/2 mice. Brain Res 613(1):49-53
abstractText  In this study we have used cortical slices prepared from genetically epilepsy-prone DBA/2 mice to investigate the effects of N-methyl-D-aspartate (NMDA) receptor stimulation on the concomitant release of nitric oxide (NO) and endogenous amino acids. DBA/2 mice exhibit an age-related susceptibility to audiogenic seizures so consequently we have compared the responses in 14-16-, 21-30- and 56-63-day-old mice. NMDA (200 microM) stimulated the release of NO and glutamate in slices prepared from 21-30-day-old animals. The release of both NO and glutamate was inhibited by the NO synthase inhibitor, L-NG-monomethylarginine (L-NG-MMA), and by haemoglobin. There was no significant NMDA-stimulated release of NO or glutamate in slices prepared from 14-16- or 56-63-day-old mice. These results support a neuromodulator role for NO in the release of transmitter and also provide evidence that the age-related susceptibility of DBA/2 mice to audiogenic seizures is related to changes in sensitivity to NMDA receptor-mediated events.
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