| Primary Identifier | MGI:1861437 | Organism | mouse, laboratory |
| Chromosome | 16 | NCBI Gene Number | 56637 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables several functions, including beta-catenin binding activity; dynein complex binding activity; and protein kinase activity. Involved in several processes, including apoptotic signaling pathway; cellular response to hormone stimulus; and positive regulation of organelle organization. Acts upstream of with a positive effect on autosome genomic imprinting. Acts upstream of or within several processes, including cellular response to hepatocyte growth factor stimulus; positive regulation of protein metabolic process; and regulation of neuron projection development. Located in several cellular components, including dendritic shaft; growth cone; and postsynaptic density. Part of Wnt signalosome; beta-catenin destruction complex; and ribonucleoprotein complex. Is active in glutamatergic synapse and meiotic spindle. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease; amyotrophic lateral sclerosis; bipolar disorder; oral squamous cell carcinoma; and schizophrenia. Orthologous to human GSK3B (glycogen synthase kinase 3 beta). PHENOTYPE: Mice homozygous for disruptions in this gene may die embryonically around mid-gestation or neonatally. When mice die neonatally, cleft palate and sternum are present. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
