| First Author | Botchkarev VA | Year | 2000 |
| Journal | Cancer Res | Volume | 60 |
| Issue | 18 | Pages | 5002-6 |
| PubMed ID | 11016618 | Mgi Jnum | J:64779 |
| Mgi Id | MGI:1889973 | Citation | Botchkarev VA, et al. (2000) p53 is essential for chemotherapy-induced hair loss. Cancer Res 60(18):5002-6 |
| abstractText | Anticancer drugs stimulate apoptosis in the hair follicles (HF) and cause hair loss, the most common side effect of chemotherapy. In a mouse model for chemotherapy-induced hair loss, we demonstrate that p53 is essential for this process: in contrast to wild-type mice, p53-deficient mice show neither hair loss nor apoptosis in the HF keratinocytes that maintained active proliferation after cyclophosphamide treatment. HF in p53 mutants are characterized by down-regulation of Fas and insulin-like growth factor-binding protein 3 and by increased expression of Bcl-2. These observations indicate that local pharmacological inhibition of p53 may be useful to prevent chemotherapy-associated hair loss. |
