| First Author | Teixeiro E | Year | 2004 |
| Journal | Immunity | Volume | 21 |
| Issue | 4 | Pages | 515-26 |
| PubMed ID | 15485629 | Mgi Jnum | J:93931 |
| Mgi Id | MGI:3510280 | Doi | 10.1016/j.immuni.2004.08.014 |
| Citation | Teixeiro E, et al. (2004) T cell division and death are segregated by mutation of TCRbeta chain constant domains. Immunity 21(4):515-26 |
| abstractText | We have studied the role of the T cell receptor (TCR) beta chain transmembrane and cytoplasmic domains (betaTM/Cyto) in T cell signaling. Upon antigen stimulation, T lymphocytes expressing a TCR with mutant and betaTM and Cyto domains accumulate in large numbers and are specifically defective in undergoing activation-induced cell death (AICD). The mutant TCR poorly recruits the protein adaptor Carma-1 and is subsequently impaired in activating NF-kappaB. This signaling defect leads to a reduced expression of Fas ligand (FasL) and to a reduction in AICD. These beta chain domains are involved in discriminating cell division and apoptosis. |
