| First Author | Ito D | Year | 1999 |
| Journal | J Oral Pathol Med | Volume | 28 |
| Issue | 8 | Pages | 371-6 |
| PubMed ID | 10478963 | Mgi Jnum | J:59498 |
| Mgi Id | MGI:1351733 | Doi | 10.1111/j.1600-0714.1999.tb02056.x |
| Citation | Ito D, et al. (1999) Altered growth response of oral mucosal keratinocytes in p53-deficient mice. J Oral Pathol Med 28(8):371-6 |
| abstractText | P53 has important regulatory functions in cell growth, differentiation and apoptosis. Here we analyzed the effects of p53 on the growth response of oral mucosal keratinocytes (OMKCs) using p53-deficient (p53-/-) mice. No morphological difference was found between p53-/- and wild-type (p53+/+) oral mucosa. In a long-term culture, p53-/- OMKCs continued to proliferate past the point at which p53+/+ became senescent. The percentage of p53-/- OMKCs in the G0/G1 phase was lower than that of p53+/+ OMKCs. Proliferation of cultured OMKCs induced by epidermal growth factor (EGF) and interleukin-(IL)-1alpha was more strongly enhanced in p53-/- than in p53+/+ mice. Such an enhanced response was not due to increased mRNA expression of growth factor receptors. These data suggest that p53 acts as a modulator of G1 arrest in OMKCs and is also involved in the regulation of responses to EGF and IL-1alpha without affecting the expression of their receptors. |
