| First Author | Liu Y | Year | 2014 |
| Journal | Oncogene | Volume | 33 |
| Issue | 3 | Pages | 308-15 |
| PubMed ID | 23318451 | Mgi Jnum | J:205177 |
| Mgi Id | MGI:5544185 | Doi | 10.1038/onc.2012.596 |
| Citation | Liu Y, et al. (2014) TRIM3, a tumor suppressor linked to regulation of p21(Waf1/Cip1.). Oncogene 33(3):308-15 |
| abstractText | The TRIM family of genes is largely studied because of their roles in development, differentiation and host cell antiviral defenses; however, roles in cancer biology are emerging. Loss of heterozygosity of the TRIM3 locus in approximately 20% of human glioblastomas raised the possibility that this NHL-domain containing member of the TRIM gene family might be a mammalian tumor suppressor. Consistent with this, reducing TRIM3 expression increased the incidence of and accelerated the development of platelet-derived growth factor -induced glioma in mice. Furthermore, TRIM3 can bind to the cdk inhibitor p21(WAF1/CIP1). Thus, we conclude that TRIM3 is a tumor suppressor mapping to chromosome 11p15.5 and that it might block tumor growth by sequestering p21 and preventing it from facilitating the accumulation of cyclin D1-cdk4. |
