| First Author | Meffert MK | Year | 2003 |
| Journal | Nat Neurosci | Volume | 6 |
| Issue | 10 | Pages | 1072-8 |
| PubMed ID | 12947408 | Mgi Jnum | J:85743 |
| Mgi Id | MGI:2676510 | Doi | 10.1038/nn1110 |
| Citation | Meffert MK, et al. (2003) NF-kappaB functions in synaptic signaling and behavior. Nat Neurosci 6(10):1072-8 |
| abstractText | Ca(2+)-regulated gene transcription is essential to diverse physiological processes, including the adaptive plasticity associated with learning. We found that basal synaptic input activates the NF-kappaB transcription factor by a pathway requiring the Ca(2+)/calmodulin-dependent kinase CaMKII and local submembranous Ca(2+) elevation. The p65:p50 NF-kappaB form is selectively localized at synapses; p65-deficient mice have no detectable synaptic NF-kappaB. Activated NF-kappaB moves to the nucleus and could directly transmute synaptic signals into altered gene expression. Mice lacking p65 show a selective learning deficit in the spatial version of the radial arm maze. These observations suggest that long-term changes to adult neuronal function caused by synaptic stimulation can be regulated by NF-kappaB nuclear translocation and gene activation. |
