| First Author | Ishikawa A | Year | 2009 |
| Journal | J Hered | Volume | 100 |
| Issue | 4 | Pages | 501-4 |
| PubMed ID | 19258432 | Mgi Jnum | J:153372 |
| Mgi Id | MGI:4365316 | Doi | 10.1093/jhered/esp004 |
| Citation | Ishikawa A (2009) Mapping an overdominant quantitative trait locus for heterosis of body weight in mice. J Hered 100(4):501-4 |
| abstractText | The genetic basis of heterosis has not been elucidated. Previously, a congenic mouse strain with a 44-Mb genomic region of proximal chromosome 2 containing the allele derived from wild Mus musculus castaneus at Pbwg1, a quantitative trait locus (QTL) for body weight and growth, has been developed. In this study, to fine-map and characterize body weight QTLs on the congenic region, QTL analysis of body weight at 1, 3, 6, and 10 weeks after birth was performed on a population of 265 F(2) intercross mice between the developed congenic strain and its background strain C57BL/6J. A significant QTL (named Pbwg1.10) affecting body weight at 6 and 10 weeks of age was identified within an approximately 21-Mb support interval. Surprisingly, Pbwg1.10 had an overdominance effect and caused heterosis for body weight. This result supported the overdominance hypothesis explaining heterosis. |
