| First Author | Weichenhan D | Year | 1998 |
| Journal | Genet Res | Volume | 71 |
| Issue | 2 | Pages | 119-25 |
| PubMed ID | 9717434 | Mgi Jnum | J:49053 |
| Mgi Id | MGI:1276623 | Doi | 10.1017/s0016672398003206 |
| Citation | Weichenhan D, et al. (1998) Restoration of the Mendelian transmission ratio by a deletion in the mouse chromosome 1 HSR. Genet Res 71(2):119-25 |
| abstractText | The house mouse, Mus musculus, harbours a variable cluster of long-range repeats in chromosome 1. As shown in previous studies, some high-copy clusters such as the MUT cluster are cytogenetically apparent as a homogeneously staining region (HSR) and are associated with a distortion of the Mendelian recovery ratio when transmitted by heterozygous females. The effect is caused by a decreased viability of +/+ embryos. It is compensated by maternal or paternal MUT. In this study, a deletion derivative of MUT, MUTdel, shows normal transmission ratios and no compensating capability. In this respect, MUTdel behaves like a wild-type cluster. Hence, both properties--transmission ratio distortion and compensating capability--map to the deleted region. The deletion comprises three-quarters of the MUT HSR and does not extend to the nearest markers adjacent to the HSR. |
