| First Author | Cheng CM | Year | 2003 |
| Journal | J Neurosci Res | Volume | 73 |
| Issue | 1 | Pages | 1-9 |
| PubMed ID | 12815703 | Mgi Jnum | J:104820 |
| Mgi Id | MGI:3612823 | Doi | 10.1002/jnr.10634 |
| Citation | Cheng CM, et al. (2003) Insulin-like growth factor 1 is essential for normal dendritic growth. J Neurosci Res 73(1):1-9 |
| abstractText | This study evaluated somatic and dendritic growth of neurons in the frontoparietal cortex of Igf1-/- brains. Pyramidal neuron density was increased by approximately 25% (P =.005) and soma size reduced by approximately 10% (P <.001). Golgi staining revealed that cortical layer II-III neurons exhibited a significant reduction in dendritic length and complexity in Igf1 null mice. Dendritic spine density and presumably synaptic contacts were reduced by 16% (P =.002). Similar findings were obtained for cortical layer V and piriform cortex pyramids. Supporting a reduction in synapses, synaptotagmin levels were reduced by 30% (P <.02) in the Igf1 null brain. Investigation of factors critically involved in dendritic growth and synaptogenesis showed an approximately 50% reduction in cortical CDC42 protein expression (P <.001) and an approximately 10% reduction in brain cholesterol levels (P <.01) in Igf1 null mice. Evidence is presented that Igf1 deletion causes disruptions in lipid and microtubule metabolism, leading to impaired neuronal somatic and dendritic growth. Published 2003 Wiley-Liss, Inc. |
