| First Author | Rodgers RJ | Year | 1989 |
| Journal | Psychopharmacology (Berl) | Volume | 97 |
| Issue | 2 | Pages | 163-5 |
| PubMed ID | 2524855 | Mgi Jnum | J:27944 |
| Mgi Id | MGI:75578 | Doi | 10.1007/BF00442242 |
| Citation | Rodgers RJ, et al. (1989) 5HT1A agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), inhibits non-opioid analgesia in defeated mice: influence of route of administration. Psychopharmacology (Berl) 97(2):163-5 |
| abstractText | Recent studies have suggested that anxiety may be an important factor in the non-opioid analgesic response to defeat in muroid rodents. In the present study, we have examined the influence of the 5-HT1A receptor agonist, 8-OH-DPAT, on basal nociception and defeat analgesia in male DBA/2 mice. Our results show that, while devoid of intrinsic activity on the mouse tail-flick assay, 8-OH-DPAT blocks the analgetic consequences of defeat. A ten-fold potency differential was observed as a function of route of injection, with minimum effective doses of 0.1 and 1.0 mg/kg for subcutaneous and intraperitoneal administration, respectively. Although further studies are required, these preliminary data support 5-HT1A receptor involvement in the mediation of this form of adaptive pain inhibition. |
