| First Author | Shoji W | Year | 1993 |
| Journal | Jpn J Cancer Res | Volume | 84 |
| Issue | 8 | Pages | 885-92 |
| PubMed ID | 8407552 | Mgi Jnum | J:15373 |
| Mgi Id | MGI:63497 | Doi | 10.1111/j.1349-7006.1993.tb02062.x |
| Citation | Shoji W, et al. (1993) c-Myc selectively regulates the latent period and erythroid-specific genes in murine erythroleukemia cell differentiation. Jpn J Cancer Res 84(8):885-92 |
| abstractText | During the latent period of murine erythroleukemia (MEL) cell differentiation, c-myc levels showed a significant change and the overexpression of the transferred c-myc gene inhibited the commitment and differentiation of MEL cells, suggesting that c-Myc may be a key molecule for the commitment. Since c-Myc may function as a DNA binding transcription factor, we examined whether c-Myc regulates the latent period genes (hsp and hsc70, MER5, Id and Spi-1 genes) and the erythroid-specific genes [beta-globin, glycophorin, delta-aminolevulinic acid synthase (ALAS-E), GATA-1 and erythropoietin receptor (EpoR)] in the MEL cell transformant having transferred c-myc gene. The overexpression of c-myc gene affected the latent period genes in different ways: hsc and hsp 70 genes and Id gene were positively regulated, while expression of MER5 gene was repressed. While c-myc is thought to be involved in DNA replication, its overexpression showed no effect on the expression of proliferating cell specific nuclear antigen or DNA polymerase a. The overexpression of c-myc repressed the expression of glycophorin, ALAS-E and beta-globin genes, of the five erythroid-specific genes, but had no effect on expression of GATA-1 or EpoR gene. These results suggest that c-Myc differentially regulates the expression of the latent period and erythroid-specific genes. |
