| First Author | Frank MG | Year | 2002 |
| Journal | Neuropsychopharmacology | Volume | 27 |
| Issue | 5 | Pages | 869-73 |
| PubMed ID | 12431861 | Mgi Jnum | J:106164 |
| Mgi Id | MGI:3617696 | Doi | 10.1016/S0893-133X(02)00353-6 |
| Citation | Frank MG, et al. (2002) Sleep and sleep homeostasis in mice lacking the 5-HT2c receptor. Neuropsychopharmacology 27(5):869-73 |
| abstractText | Studies in humans and rats indicate that serotonin (5-hydroxytryptamine, 5-HT) receptors are involved in mammalian sleep expression. We investigated the contribution of the 5-HT2c receptor to sleep expression by examining sleep patterns in mice bearing a targeted null mutation of this receptor. 5-HT2c receptor knock-out mice had more wakefulness, several abnormalities in rapid eye movement sleep expression and an enhanced response to sleep deprivation compared with wild-type control mice. These findings suggest that 5HT2c receptors may mediate several effects on sleep that have been ascribed to serotonin. |
