|  Help  |  About  |  Contact Us

Allele : Tg(APOE-CYP4B1)1Yfsi transgene insertion 1, Yoshihiko Funae and Susumu Imaoka
Primary Identifier  MGI:3054634 Allele Type  Transgenic
Attribute String  Inserted expressed sequence Gene  Tg(APOE-CYP4B1)1Yfsi
Strain of Origin  (C57BL/6CrSlc x DBA/2CrSlc)F2 Is Recombinase  false
Is Wild Type  false
molecularNote  The transgene comprises the entire coding sequence of human cytochrome P450, family 4, subfamily b, polypeptide 1 (CYP4B1) cDNA coupled to the 5' flanking region and hepatic control sequence of the human apolipoprotein E gene. Immunoblot analysis of hepatic microsomes from transgenic mice revealed an immunoreactive protein having the mobility of human CYP4B1. Lauric acid omega-hydroxylation was 25% greater and mutagenic activation of 2-aminofluorene two-fold greater in transgenic than in control liver microsomes; both these activities were abrogated by antibodies to CYP4B1.
  • mutations:
  • Insertion
Paste the following link
Quick Links:
SummaryGenomePhenotypeOther
 
Quick Links:
SummaryGenomePhenotypeOther
 
Lists
This Allele isn't in any lists. Upload a list.

1 Feature

Trail: Allele

Genome

1 Expresses

Trail: Allele

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

Trail: Allele

0 Driven By

2 Publication categories

Trail: Allele




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom