| First Author | Harker JA | Year | 2013 |
| Journal | Immunity | Volume | 39 |
| Issue | 3 | Pages | 548-59 |
| PubMed ID | 23993651 | Mgi Jnum | J:208221 |
| Mgi Id | MGI:5562497 | Doi | 10.1016/j.immuni.2013.08.010 |
| Citation | Harker JA, et al. (2013) Cell-intrinsic IL-27 and gp130 cytokine receptor signaling regulates virus-specific CD4(+) T cell responses and viral control during chronic infection. Immunity 39(3):548-59 |
| abstractText | The outcome of chronic viral infections, which affect millions of people worldwide, is greatly dependent on CD4(+) T cells. Here we showed that T cell-specific ablation of the common interleukin-6 (IL-6) family receptor, gp130, profoundly compromised virus-specific CD4(+) T cell survival, T follicular helper responses, and IL-21 production at late stages of chronic lymphocytic choriomeningitis virus (LCMV) infection. These effects were cell intrinsic for CD4(+) T cells and were accompanied by a reduction of CD8(+) T cells, antibodies, and a severe failure in viral control. We identified IL-27 as a gp130 cytokine that promoted antiviral CD4(+) T cell accumulation in vivo and that rapidly induced IL-21 ex vivo. Furthermore, IL-27R was critical for control of persistent LCMV in vivo. These results reveal that gp130 cytokines (particularly IL-27) are key regulators of CD4(+) T cell responses during an established chronic viral infection, empowering both humoral and cytotoxic immunity. |
