| First Author | Hashimoto Y | Year | 2009 |
| Journal | Biochem Biophys Res Commun | Volume | 389 |
| Issue | 1 | Pages | 95-9 |
| PubMed ID | 19703422 | Mgi Jnum | J:153530 |
| Mgi Id | MGI:4365677 | Doi | 10.1016/j.bbrc.2009.08.095 |
| Citation | Hashimoto Y, et al. (2009) Identification of soluble WSX-1 not as a dominant-negative but as an alternative functional subunit of a receptor for an anti-Alzheimer's disease rescue factor Humanin. Biochem Biophys Res Commun 389(1):95-9 |
| abstractText | Humanin (HN) inhibits Alzheimer's disease (AD)-relevant neuronal death and dysfunction, by interacting with a receptor (s) involving ciliary neurotrophic factor receptor alpha (CNTFR), WSX-1, and gp130. It remains unknown whether this complex is the sole HN receptor that mediates HN-induced anti-AD activity. We here report that an alternatively spliced WSX-1 isoform, encoding an extracellular 270-amino-acid region of WSX-1 with cytokine-binding regions (named soluble WSX-1; sWSX-1), is expressed in neuronal cells lacking function of full-length WSX-1 and enables HN to rescue AD-relevant death. This result suggests that CNTFR/soluble WSX-1/gp130 behaves as an alternative functional HN receptor. |
