| First Author | Kim J | Year | 1999 |
| Journal | Immunity | Volume | 10 |
| Issue | 3 | Pages | 345-55 |
| PubMed ID | 10204490 | Mgi Jnum | J:54004 |
| Mgi Id | MGI:1333986 | Doi | 10.1016/s1074-7613(00)80034-5 |
| Citation | Kim J, et al. (1999) Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes. Immunity 10(3):345-55 |
| abstractText | The Ikaros gene family encodes zinc finger DNA-binding proteins essential for lineage determination and control of proliferation in the lymphoid system. Here, we report that, in the nucleus of a T cell, a major fraction of Ikaros and Aiolos proteins associate with the DNA- dependent ATPase Mi-2 and histone deacetylases, in a 2 MD complex. This Ikaros-NURD complex is active in chromatin remodeling and histone deacetylation. Upon T cell activation, Ikaros recruits Mi-2/HDAC to regions of heterochromatin. These studies reveal that Ikaros proteins are capable of targeting chromatin remodeling and deacetylation complexes in vivo. We propose that the restructuring of chromatin is a key aspect of Ikaros function in lymphocyte differentiation. |
