| First Author | Baker JR | Year | 2011 |
| Journal | Dev Dyn | Volume | 240 |
| Issue | 9 | Pages | 2194-203 |
| PubMed ID | 22016186 | Mgi Jnum | J:177483 |
| Mgi Id | MGI:5295300 | Doi | 10.1002/dvdy.22709 |
| Citation | Baker JR, et al. (2011) Distinct roles for S100a8 in early embryo development and in the maternal deciduum. Dev Dyn 240(9):2194-203 |
| abstractText | S100a8 is a cytosolic protein expressed in myeloid cells where it forms a stable heterodimer with another S100 protein family member, S100a9. The S100a9(-/-) mouse is viable and phenotypically normal, whereas the S100a8(-/-) condition is embryonic lethal. We present evidence that S100a8, without S100a9, has a previously unrecognized role in embryo development between fertilization and the 8-cell stage at embryonic day (E) 2.5. S100a8 also has a second role in the maternal deciduum, where expression is associated with the vasculature from the E8.5 stage to the formation of mature placenta. Uterine natural killer cells that have a role in vascular remodelling colocalise with the S100a8 vascular expression in the metrial triangle. In inflammatory responses in peripheral tissues, S100a8 is a potent chemoattractant and also an anti-oxidant. Both roles may be important in the developing placenta. Thus we highlight two new S100a9-independent roles for S100a8 in early embryo development. Developmental Dynamics 240:2194-2203, 2011. (c) 2011 Wiley-Liss, Inc. |
