| First Author | Horikawa I | Year | 1995 |
| Journal | Biochem Biophys Res Commun | Volume | 208 |
| Issue | 3 | Pages | 999-1007 |
| PubMed ID | 7702631 | Mgi Jnum | J:24182 |
| Mgi Id | MGI:71936 | Doi | 10.1006/bbrc.1995.1433 |
| Citation | Horikawa I, et al. (1995) Molecular cloning of a novel human cDNA on chromosome 1q21 and its mouse homolog encoding a nuclear protein with DNA-binding ability. Biochem Biophys Res Commun 208(3):999-1007 |
| abstractText | We previously reported that human chromosome 1q21 or 1q23-q24 carries a transformation suppressor gene(s) for Kirsten sarcoma virus-transformed NIH3T3 cells. In this study, we have isolated a novel human cDNA on 1q21 (designated as YL-1) as a candidate, then cloned its mouse homolog. Human and mouse YL-1 cDNA shared 96% in amino acid homology and presumably encoded a transcription factor-like polypeptide. An analysis using a specific antibody revealed the nuclear localization of YL-1 protein. The bacterially expressed YL-1 could bind to DNA. Thus, YL-1 protein possibly functions as a transcriptional regulator. |
