| First Author | Ray A | Year | 2019 |
| Journal | Nat Commun | Volume | 10 |
| Issue | 1 | Pages | 190 |
| PubMed ID | 30643147 | Mgi Jnum | J:272027 |
| Mgi Id | MGI:6277402 | Doi | 10.1038/s41467-018-08122-9 |
| Citation | Ray A, et al. (2019) Mature IgD(low/-) B cells maintain tolerance by promoting regulatory T cell homeostasis. Nat Commun 10(1):190 |
| abstractText | A number of different B cell subsets have been shown to exhibit regulatory activity using a variety of mechanisms to attenuate inflammatory diseases. Here we show, using anti-CD20-mediated partial B cell depletion in mice, that a population of mature B cells distinguishable by IgD(low/-) expression maintains tolerance by, at least in part, promoting CD4(+)Foxp3(+) regulatory T cell homeostatic expansion via glucocorticoid-induced tumor necrosis factor receptor ligand, or GITRL. Cell surface phenotyping, transcriptome analysis and developmental study data show that B cells expressing IgD at a low level (BDL) are a novel population of mature B cells that emerge in the spleen from the transitional-2 stage paralleling the differentiation of follicular B cells. The cell surface phenotype and regulatory function of BDL are highly suggestive that they are a new B cell subset. Human splenic and peripheral blood IgD(low/-) B cells also exhibit BDL regulatory activity, rendering them of therapeutic interest. |
