| First Author | Rosen LL | Year | 1990 |
| Journal | Genomics | Volume | 8 |
| Issue | 1 | Pages | 134-40 |
| PubMed ID | 1981992 | Mgi Jnum | J:11080 |
| Mgi Id | MGI:59522 | Doi | 10.1016/0888-7543(90)90235-m |
| Citation | Rosen LL, et al. (1990) Molecular cloning of the t complex responder genetic locus. Genomics 8(1):134-40 |
| abstractText | Although mouse t haplotypes carry recessive mutations causing male sterility and embryonic lethality, they persist in wild mouse populations via male transmission ratio distortion (TRD). Genetic evidence suggests that at least five t-haplotype-encoded loci combine to cause TRD. One of these loci, called the t complex responder (Tcr), is absolutely required for any deviation from Mendelian segregation to occur. A candidate for the Tcr gene has previously been identified. Evidence that this gene represents Tcr is its localization to the appropriate genomic subregion and testis-specific expression pattern. Here, we report the molecular cloning of the region between recombinant chromosome breakpoints defining the Tcr locus. These results circumscribe Tcr to a 150- to 220-kb region of DNA, including the 22-kb candidate responder gene. This gene and two other homologs were created by large genomic duplications, each involving segments of DNA 10-fold larger than the individual genes. |
