| First Author | Nanba D | Year | 2003 |
| Journal | Anat Rec A Discov Mol Cell Evol Biol | Volume | 270 |
| Issue | 2 | Pages | 97-102 |
| PubMed ID | 12524684 | Mgi Jnum | J:81508 |
| Mgi Id | MGI:2449433 | Doi | 10.1002/ar.a.10012 |
| Citation | Nanba D, et al. (2003) Establishment of cadherin-based intercellular junctions in the dermal papilla of the developing hair follicle. Anat Rec A Discov Mol Cell Evol Biol 270(2):97-102 |
| abstractText | During hair follicle development, mesenchymal cells aggregate to form the dermal papilla with hair-inducing activity. However, the cellular mechanisms underlying the aggregative behavior of dermal papilla cells are less known. The present study demonstrates that cadherin-based intercellular junctions interconnect dermal papilla cells in developing hair follicles of mice. It is shown that as mesenchymal cells aggregate to be surrounded by epithelium in developing hair follicles, cadherin-11 comes to exhibit the dotted patterns of distribution. The appearance of the dot-like distribution of the molecule is concomitant with the formation of intercellular junctions in the mesenchymal aggregate, which make a tightly packed population of cells with little extracellular space. At later stages of the development, although extracellular space reappears in the dermal papilla, the cells remain interconnected by well-developed intercellular junctions, where cadherin-11 as well as beta-catenin is localized. Taking into consideration the normal hair development in cadherin-11 mutant mice, it might be that multiple cadherins are responsible for the establishment of intercellular junctions in the dermal papilla and serve to maintain the aggregative behavior of the cells. Anat Rec Part A 270A:97-102, 2003. |
