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Protein Coding Gene : Kdm2a lysine (K)-specific demethylase 2A

Primary Identifier  MGI:1354736 Organism  Mus musculus
Chromosome  19 NCBI Gene Number  225876
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 5.4.0)

Enables unmethylated CpG binding activity. Involved in histone H3-K36 demethylation. Acts upstream of or within several processes, including epithelial tube morphogenesis; neuroepithelial cell differentiation; and regulation of gene expression. Is active in chromatin. Is expressed in embryo; forebrain; and limb. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human KDM2A (lysine demethylase 2A).
PHENOTYPE: Mice homozygous for a null allele show embryonic lethality, severe growth retardation, reduced neuron proliferation, increased neuron apoptosis, impaired neuron differentiation, small hearts, abnormal cardiac looping and, in some cases, incomplete embryonic turning and neural tube closure defects. [provided by MGI curators]
  • synonyms:
  • F-box and leucine-rich repeat protein 11,
  • Kdm2a,
  • expressed sequence AW536790,
  • Fbxl11,
  • Fbl7,
  • predicted gene, 100043628,
  • AW536790,
  • Jhdm1a,
  • lysine (K)-specific demethylase 2A,
  • Cxxc8,
  • MGI:3782744,
  • 100043628,
  • Gm4560,
  • MGI:2147454,
  • 5530401A10Rik,
  • lalina,
  • predicted gene 4560,
  • expressed sequence AA589516,
  • MGI:1918681,
  • RIKEN cDNA 5530401A10 gene,
  • MGI:2147738,
  • AA589516

Features --> Cross References

Genome

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0 Exons

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0 Involved In Mutations

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0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

3 Pathways

675 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications