| Primary Identifier | IPR028727 | Type | Family |
| Short Name | CHD5 |
| description | There are nine members of the Chromodomain, Helicase, DNA-binding (CHD) family. They are characterised by two chromodomains arranged in tandem, N-terminal to the ATPase/helicase domain. Chromodomains are comprised of a β-sheet folded against an α-helix that collectively mediates binding to methyl-lysine residues []. This entry represent chromodomain-helicase-DNA-binding protein 5 (CHD5). CHD5 is almost exclusively expresssed in brain and testis, and is required for spermiogenesis and chromatin condensation []. CHD5 plays a role in the development of the nervous system [, , ]. It has been identified as a tumour suppressor []. |
