| First Author | Yeh ET | Year | 2000 |
| Journal | Gene | Volume | 248 |
| Issue | 1-2 | Pages | 1-14 |
| PubMed ID | 10806345 | Mgi Jnum | J:62211 |
| Mgi Id | MGI:1858577 | Doi | 10.1016/s0378-1119(00)00139-6 |
| Citation | Yeh ET, et al. (2000) Ubiquitin-like proteins: new wines in new bottles. Gene 248(1-2):1-14 |
| abstractText | Ubiquitin is a small polypeptide that covalently modifies other cellular proteins and targets them to the proteasome for degradation. In recent years, ubiquitin-dependent proteolysis has been demonstrated to play a critical role in the regulation of many cellular processes, such as cell cycle progression, cell signaling, and immune recognition. The recent discovery of three new ubiquitin-like proteins, NEDD8, Sentrin/SUMO, and Apg12, has further broadened the horizon of this type of post-translational protein modification. This review will focus on the biology and biochemistry of the Sentrin/SUMO and NEDD8 modification pathways, which are clearly distinct from the ubiquitination pathway and have unique biological functions. |
