| First Author | Alvarez JV | Year | 2013 |
| Journal | Cancer Cell | Volume | 24 |
| Issue | 1 | Pages | 30-44 |
| PubMed ID | 23770012 | Mgi Jnum | J:199068 |
| Mgi Id | MGI:5500814 | Doi | 10.1016/j.ccr.2013.05.007 |
| Citation | Alvarez JV, et al. (2013) Par-4 Downregulation Promotes Breast Cancer Recurrence by Preventing Multinucleation following Targeted Therapy. Cancer Cell 24(1):30-44 |
| abstractText | Most deaths from breast cancer result from tumor recurrence, but mechanisms underlying tumor relapse are largely unknown. We now report that Par-4 is downregulated during tumor recurrence and that Par-4 downregulation is necessary and sufficient to promote recurrence. Tumor cells with low Par-4 expression survive therapy by evading a program of Par-4-dependent multinucleation and apoptosis that is otherwise engaged following treatment. Low Par-4 expression is associated with poor response to neoadjuvant chemotherapy and an increased risk of relapse in patients with breast cancer, and Par-4 is downregulated in residual tumor cells that survive neoadjuvant chemotherapy. Our findings identify Par-4-induced multinucleation as a mechanism of cell death in oncogene-addicted cells and establish Par-4 as a negative regulator of breast cancer recurrence. |
