| First Author | Dai Z | Year | 1998 |
| Journal | Genes Dev | Volume | 12 |
| Issue | 10 | Pages | 1415-24 |
| PubMed ID | 9585502 | Mgi Jnum | J:72870 |
| Mgi Id | MGI:2153704 | Doi | 10.1101/gad.12.10.1415 |
| Citation | Dai Z, et al. (1998) Oncogenic Abl and Src tyrosine kinases elicit the ubiquitin-dependent degradation of target proteins through a Ras-independent pathway. Genes Dev 12(10):1415-24 |
| abstractText | Oncogenic forms of the Abl and Src tyrosine kinases trigger the destruction of the Abi proteins, a family of Abl-interacting proteins that antagonize the oncogenic potential of Abl after overexpression in fibroblasts. The destruction of the Abi proteins requires tyrosine kinase activity and is dependent on the ubiquitin-proteasome pathway. We show that degradation of the Abi proteins occurs through a Ras-independent pathway. Significantly, expression of the Abi proteins is lost in cell lines and bone marrow cells isolated from patients with aggressive Bcr-Abl-positive leukemias. These findings suggest that loss of Abi proteins may be a component in the progression of Bcr-Abl-positive leukemias and identify a novel pathway linking activated nonreceptor protein tyrosine kinases to the destruction of specific target proteins through the ubiquitin-proteasome pathway. |
