| First Author | Anderson A | Year | 1992 |
| Journal | Radiat Res | Volume | 130 |
| Issue | 3 | Pages | 340-4 |
| PubMed ID | 1594760 | Mgi Jnum | J:1154 |
| Mgi Id | MGI:49686 | Citation | Anderson A, et al. (1992) Cellular proto-oncogene expression following exposure of mice to gamma rays. Radiat Res 130(3):340-4 |
| abstractText | Many studies have shown the importance of altered cellular proto-oncogene expression in contributing to changes in cell survival, cell transformation, and cell cycle progression. In these experiments we examined the effects of total-body exposure of BCF1 mice to gamma rays (3 Gy) in modulating expression of cellular oncogenes in both gut and liver tissues. We selected specific cellular oncogenes (c-fos, c-myc, c-src, and c-H-ras), based on their normal expression in liver and gut tissues from untreated mice. As early as 5 min following whole-body exposure of BCF1 mice to gamma rays we detected induction of mRNA specific for c-src and c-H-ras in both liver and gut tissues. Accumulation of c-fos-RNA was slightly decreased in gut but was unaffected in liver tissue from irradiated mice relative to untreated controls. Accumulation of c-myc mRNA was unaffected in all tissues examined. These experiments document that modulation of cellular proto-oncogene expression can occur as an early event in tissues following irradiation and suggest that this modulation may play a role in radiation-induced cellular changes. |
