Primary Identifier | MGI:2444554 | Organism | mouse, laboratory |
Chromosome | 2 | NCBI Gene Number | 227743 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0) Predicted to enable several functions, including enzyme binding activity; phosphatidylinositol-3,4-bisphosphate binding activity; and phospholipid binding activity. Involved in positive regulation of peptidyl-serine phosphorylation and regulation of cellular response to oxidative stress. Part of TORC2 complex. Is expressed in genitourinary system; gut gland; heart; nervous system; and trachea. Orthologous to human MAPKAP1 (MAPK associated protein 1). PHENOTYPE: Homozygous null mice exhibit embryonic lethality due to early developmental abnormalities. Mutant mouse embryonic fibroblasts display increased susceptibility to stress-induced apoptosis. [provided by MGI curators] |