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Protein Coding Gene : Acox2 acyl-Coenzyme A oxidase 2, branched chain

Primary Identifier  MGI:1934852 Organism  mouse, laboratory
Chromosome  14 NCBI Gene Number  93732
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.4.0)

Predicted to enable several functions, including 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity; anion binding activity; and palmitoyl-CoA oxidase activity. Predicted to be involved in bile acid biosynthetic process; fatty acid beta-oxidation using acyl-CoA oxidase; and very long-chain fatty acid metabolic process. Predicted to be located in cytosol and intracellular membrane-bounded organelle. Predicted to be active in peroxisome. Is expressed in several structures, including heart ventricle; liver; metanephros; and trunk. Human ortholog(s) of this gene implicated in congenital bile acid synthesis defect 6. Orthologous to human ACOX2 (acyl-CoA oxidase 2).
PHENOTYPE: About 29% of mice homozygous for an endonuclease-mediated deletion spontaneously develop liver cancer at 8-9 months and exhibit liver inflammation and bile duct proliferation. [provided by MGI curators]
  • synonyms:
  • Acox2,
  • acyl-Coenzyme A oxidase 2, branched chain

Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

0 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

11 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

1 Driver For