Primary Identifier | MGI:1934852 | Organism | mouse, laboratory |
Chromosome | 14 | NCBI Gene Number | 93732 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.4.0) Predicted to enable several functions, including 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity; anion binding activity; and palmitoyl-CoA oxidase activity. Predicted to be involved in bile acid biosynthetic process; fatty acid beta-oxidation using acyl-CoA oxidase; and very long-chain fatty acid metabolic process. Predicted to be located in cytosol and intracellular membrane-bounded organelle. Predicted to be active in peroxisome. Is expressed in several structures, including heart ventricle; liver; metanephros; and trunk. Human ortholog(s) of this gene implicated in congenital bile acid synthesis defect 6. Orthologous to human ACOX2 (acyl-CoA oxidase 2). PHENOTYPE: About 29% of mice homozygous for an endonuclease-mediated deletion spontaneously develop liver cancer at 8-9 months and exhibit liver inflammation and bile duct proliferation. [provided by MGI curators] |