Primary Identifier | MGI:6202965 | Allele Type | Endonuclease-mediated |
Attribute String | Humanized sequence | Gene | Mthfr |
Strain of Origin | B6(SJL)-Apoe<tm1.1(APOE*4)Adiuj> Trem2<em1Adiuj>/J | Is Recombinase | false |
Is Wild Type | false |
molecularNote | CRISPR/Cas9 genome editing is used to introduce a point mutation (GCC to GTC) creating the A262V mutation. This C to T mutation is homologous to the human C677T polymorphism that has been associated with various diseases including Alzheimer's, vascular and metabolic disease. |