| First Author | Derry JM | Year | 1995 |
| Journal | Hum Mol Genet | Volume | 4 |
| Issue | 12 | Pages | 2307-11 |
| PubMed ID | 8634703 | Mgi Jnum | J:43904 |
| Mgi Id | MGI:1099123 | Doi | 10.1093/hmg/4.12.2307 |
| Citation | Derry JM, et al. (1995) RBM3, a novel human gene in Xp11.23 with a putative RNA-binding domain. Hum Mol Genet 4(12):2307-11 |
| abstractText | Using cDNA selection with a YAC from the Xp11.2 region, we have identified a novel gene (RBM3) that encodes a polypeptide with high sequence similarity to a group of proteins that bind to RNA. On a YAC contig map, RBM3 is located between OATL1 and GATA1/TFE3 in sub-band Xp11.23, and gives rise to alternatively spliced transcripts in a variety of human tissues. The longest open reading frame encodes a 157 amino acid protein with a predicted molecular weight of 17 kDa. Its putative RNA-binding domain most closely resembles that of two previously characterized human RNA-binding proteins, YRRM, the gene for which has been implicated in azoospermia, and hnRNP G, a glycoprotein, also identified as an auto-antigen. The homology of RMB3 in both sequence and size to an RNA binding protein from maize, AAIP , suggests that it functions in a fundamental pathway conserved from plants to mammals. |
