| First Author | Disney JE | Year | 1992 |
| Journal | Cytogenet Cell Genet | Volume | 59 |
| Issue | 1 | Pages | 39-44 |
| PubMed ID | 1733671 | Mgi Jnum | J:1956 |
| Mgi Id | MGI:50480 | Doi | 10.1159/000133196 |
| Citation | Disney JE, et al. (1992) Defective repair of radiation-induced chromosomal damage in scid/scid mice. Cytogenet Cell Genet 59(1):39-44 |
| abstractText | The murine severe combined immunodeficiency (scid) mutation interferes with normal recombination of immunoglobulin and T-cell receptor genes. This immunologic defect results in a lack of fully differentiated B and T cells in scid/scid mice. Animals homozygous for the scid mutation also display increased sensitivity to the damaging effects of ionizing radiation. We report here our observations of high frequencies of radiation-induced chromatid interchanges and intrachanges in bone marrow cells and fibroblasts from scid/scid mice. The presence of these aberrant chromosome structures suggests that a delay in strand rejoining underlies the increased sensitivity of scid/scid mice to ionizing radiation. The scid mutation may provide important clues for understanding the relationship between mitotic recombination and DNA repair in higher eukaryotic cells. |
