| First Author | Xing L | Year | 2001 |
| Journal | Genes Dev | Volume | 15 |
| Issue | 2 | Pages | 241-53 |
| PubMed ID | 11157779 | Mgi Jnum | J:67400 |
| Mgi Id | MGI:1930473 | Doi | 10.1101/gad.840301 |
| Citation | Xing L, et al. (2001) Genetic evidence for a role for Src family kinases in TNF family receptor signaling and cell survival. Genes Dev 15(2):241-53 |
| abstractText | Mutant src(-/-) mice have osteopetrosis resulting from defective osteoclasts, the cells that resorb bone. However, signaling pathways involving Src family members in osteoclasts remain unclear. We demonstrate that expression of a truncated Src molecule, Src251, lacking the kinase domain, induces osteopetrosis in wild-type and src(+/-) mice and worsens osteopetrosis in src(-/-) mice by a novel mechanism, increased osteoclast apoptosis. Induction of apoptosis by Src251 requires a functional SH2, but not an SH3, domain and is associated with reduced AKT kinase activity. Expression of Src251 dramatically reduces osteoclast survival in response to RANKL/TRANCE/OPGL, providing evidence that Src family kinases are required in vivo for survival signaling pathways downstream from TNF family receptors. |
