|  Help  |  About  |  Contact Us

Publication : Cloning and characterization of the multiple murine homologues of NAIP (neuronal apoptosis inhibitory protein).

First Author  Yaraghi Z Year  1998
Journal  Genomics Volume  51
Issue  1 Pages  107-13
PubMed ID  9693038 Mgi Jnum  J:49067
Mgi Id  MGI:1276637 Doi  10.1006/geno.1998.5378
Citation  Yaraghi Z, et al. (1998) Cloning and characterization of the multiple murine homologues of NAIP (neuronal apoptosis inhibitory protein). Genomics 51(1):107-13
abstractText  The spinal muscular atrophies (SMAs), characterized by degeneration of spinal cord motor neurons, are among the most common autosomal recessive disorders. We have previously reported the characterization of an SMA-associated gene designated NAIP (neuronal apoptosis inhibitory protein). This gene, which encodes a protein homologous to the baculoviral inhibitor of apoptosis proteins, is deleted in a significant proportion of individuals with type I SMA, is expressed in motor neurons, and inhibits apoptosis both in vitro and in vivo. Here we present the cloning and character-ization of multiple copies of the mouse homologue of NAIP, Naip1-Naip6. Our analysis of the genomic organization of Naip indicated the existence of a minimum of six distinct Naip loci in the 129/SvJ mouse strain. However, Southern blot analysis revealed that only three of these loci contained the 5'UTR element essential for translation in the CNS. The coding region of one of these three potentially functional loci (Naip1) demonstrates 77% homology to NAIP at the nucleotide level and 68% identity at the amino acid level. Copyright 1998 Academic Press.
Quick Links:
 
Quick Links:
 

Expression

Publication --> Expression annotations

 

Other

8 Bio Entities

Trail: Publication

0 Expression