| First Author | Miyagi S | Year | 2008 |
| Journal | FEBS Lett | Volume | 582 |
| Issue | 18 | Pages | 2811-5 |
| PubMed ID | 18638478 | Mgi Jnum | J:138323 |
| Mgi Id | MGI:3804786 | Doi | 10.1016/j.febslet.2008.07.011 |
| Citation | Miyagi S, et al. (2008) Consequence of the loss of Sox2 in the developing brain of the mouse. FEBS Lett 582(18):2811-5 |
| abstractText | The transcription factor Sox2 is expressed at high levels in neural stem and progenitor cells. Here, we inactivated Sox2 specifically in the developing brain by using Cre-loxP system. Although mutant animals did not survive after birth, analysis of late gestation embryos revealed that loss of Sox2 causes enlargement of the lateral ventricles and a decrease in the number of neurosphere-forming cells. However, although their neurogenic potential is attenuated, Sox2-deficient neural stem cells retain their multipotency and self-renewal capacity. We found that expression level of Sox3 is elevated in Sox2 null developing brain, probably mitigating the effects of loss of Sox2. |
