| First Author | Pan YX | Year | 1998 |
| Journal | FEBS Lett | Volume | 435 |
| Issue | 1 | Pages | 65-8 |
| PubMed ID | 9755860 | Mgi Jnum | J:50054 |
| Mgi Id | MGI:1289791 | Doi | 10.1016/s0014-5793(98)01039-4 |
| Citation | Pan YX, et al. (1998) Identification and differential regional expression of KOR-3/ORL-1 gene splice variants in mouse brain. FEBS Lett 435(1):65-8 |
| abstractText | KOR-3, also known as ORL-1, is a member of the opioid receptor family, encoding the murine receptor for orphanin FQ/nociceptin. In the current studies we have identified five different splice variants of KOR-3 in mouse brain, three of which have not been previously reported. In addition to variants with a 15 bp deletion at the 3'-end of the first coding exon (KOR-3d) and an 81 bp insertion between the second and third coding exons (KOR-3e), three new variants with insertions of 34 (KOR-3a), 98 (KOR-3b), and 139 bp (KOR-3c) between the first and second coding exons have been obtained. The expression of the three variants in mouse brain varies markedly among brain regions with a distribution which is quite distinct from KOR-3 itself. Of greatest interest was the presence of high levels of KOR-3a in the striatum, a region with no demonstrable KOR-3, and in the cortex. KOR-3c was seen in the periaqueductal gray and hypothalamus, regions where KOR-3 predominated. The brainstem had similar levels of KOR-3, KOR-3a, and KOR-3d. In contrast, KOR-3d was most prominent in the cerebellum. KOR-3b levels were very low throughout. |
