| Primary Identifier | MGI:2388562 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(Hoxb7-RET-M918T)2Vpa |
| Strain of Origin | Not Specified | Is Recombinase | false |
| Is Wild Type | false |
| description | Trangenic founder mice were sacrificed at day E18.5 for analysis. |
| molecularNote | The transgene consists of a human RET cDNA encoding the RET51 isoform with a methionine to threonine substitution at position 918 (M918T) fused to mouse Hoxb7 promoter sequences (-1316 to +81). Mouse Hoxb7 promoter was used to drive expression of the transgene throughout the uretic bud branches. The M918T mutation is associated with the human disease MEN2B syndrome. |
