| First Author | Hall RJ | Year | 2003 |
| Journal | Mamm Genome | Volume | 14 |
| Issue | 5 | Pages | 335-9 |
| PubMed ID | 12856285 | Mgi Jnum | J:83136 |
| Mgi Id | MGI:2657061 | Doi | 10.1007/s00335-002-3064-8 |
| Citation | Hall RJ, et al. (2003) An autoimmune diabetes locus (Idd21) on mouse chromosome 18. Mamm Genome 14(5):335-9 |
| abstractText | Twenty-four named Idd loci that contribute to the development of autoimmune diabetes in the nonobese diabetic (NOD) mouse have been mapped by linkage and congenic analysis. Previously, meta-analysis of genome-wide linkage scans supported the existence of a locus for susceptibility to autoimmune phenotypes on rodent Chromosome (Chr) 18, in a position orthologous to the human typc 1 diabetes susceptibility locus IDDM6 (human Chr 18q12-q23). However, an autoimmune diabetes susceptibility locus has not previously been reported on mouse Chr 18. In this study, we demonstrate linkage of the majority of mouse Chr 18 to diabetes in a (ABH x NOD)F1 x NOD backcross. Congenic analysis, introgressing at least 92% of Biozzi ABH Chr 18 onto the NOD background, confirmed the presence of a diabetes locus. The chromosome substitution strain (NOD.ABH-Chr18) had reduced diabetes incidence compared with NOD mice (P < 0.0001). We have named the Chr 18 diabetes locus Idd21. |
