| Primary Identifier | IPR044120 | Type | Domain |
| Short Name | STKc_Nek8 |
| description | Nek8 contains an N-terminal kinase catalytic domain and a C-terminal RCC1 (regulator of chromosome condensation) domain. Nek8 human mutations have been shown to cause major organ developmental defects due to altered ciliogenesis and cell differentiation/proliferation through deregulation of the Hippo pathway []. Nek8 is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control [].This entry represents the catalytic domain of Nek8. |
