| First Author | Filali M | Year | 2009 |
| Journal | Brain Res | Volume | 1292 |
| Pages | 93-9 | PubMed ID | 19643098 |
| Mgi Jnum | J:157207 | Mgi Id | MGI:4430169 |
| Doi | 10.1016/j.brainres.2009.07.066 | Citation | Filali M, et al. (2009) Age-related cognitive decline and nesting behavior in an APPswe/PS1 bigenic model of Alzheimer's disease. Brain Res 1292:93-9 |
| abstractText | A large series of 3-, 6-, 9-, and 12-month-old bigenic mice (N=240) with Swedish APP and A246E PS1 mutations was investigated in nest-building, spontaneous alternation, and two learning tasks. Progressive cognitive impairment was observed in APPswe/PS1 mice relative to controls for nest-building, spontaneous alternation, the reversal phase of left-right discrimination learning in a water-filled T-maze, and in retention of passive avoidance learning. The behavioral deficits in transgenic mice start at 6 months, appearing to offer an opportunity for assessing potential therapeutic agents in attenuating or preventing Alzheimer's disease. |
