| Primary Identifier | MGI:109298 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 17164 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables protein serine/threonine kinase activity. Involved in several processes, including macropinocytosis; regulation of cytokine production; and response to lipopolysaccharide. Acts upstream of or within inner ear development; p38MAPK cascade; and positive regulation of gene expression. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and immune system. Orthologous to human MAPKAPK2 (MAPK activated protein kinase 2). PHENOTYPE: Inactivation of this locus affects the inflammatory response. Homozygous null mice show an increased susceptibility to bacterial infection. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
