| Primary Identifier | MGI:106015 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 20463 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Involved in mitochondrial respirasome assembly and regulation of oxidative phosphorylation. Located in mitochondrial respirasome. Is expressed in several structures, including alimentary system; facial bone primordium; nervous system; respiratory system; and sensory organ. Orthologous to human COX7A2L (cytochrome c oxidase subunit 7A2 like). PHENOTYPE: Mice homozygous for a null allele exhibit decreased running capacity, decrease in metabolic rate and mitochondrial oxidative capacity, whitened brown adipose tissue and severe cold sensitivity. Mice homozygous for an allele encoding the short isoform exhibit higher succinate or pyruvate and malate-driven respiration rates [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
