| First Author | Laffont S | Year | 2010 |
| Journal | Eur J Immunol | Volume | 40 |
| Issue | 7 | Pages | 1877-83 |
| PubMed ID | 20432234 | Mgi Jnum | J:161863 |
| Mgi Id | MGI:4461830 | Doi | 10.1002/eji.200939957 |
| Citation | Laffont S, et al. (2010) Intestinal inflammation abrogates the tolerogenic properties of MLN CD103(+) dendritic cells. Eur J Immunol 40(7):1877-1883 |
| abstractText | Intestinal CD103(+) DC promote the differentiation of Foxp3(+) Treg from naive CD4(+) T cells through mechanisms involving TGF-beta and the dietary metabolite, retinoic acid (RA). In this study, we have analysed whether the specialised features of CD103(+) DC are conserved in colitis. Our results show that inflammation dampens the tolerogenic properties of MLN CD103(+) DC, which is associated with lower expression of tgfbeta2 and aldh1a2. Accordingly, CD103(+) DC taken from colitic mice are impaired in their ability to induce Foxp3(+) Treg and instead favour the emergence of IFN-gamma-producing CD4(+) T cells compared with their steady-state counterparts. BrdU-labelling studies and analysis of ontogeny markers show that CD103(+) DC from steady-state and colitic settings retain similar subset composition and developmental pathways. These results indicate that MLN CD103(+) DC are not hard-wired to promote tolerance but can adapt to environmental conditions. The inflammatory properties of MLN CD103(+) DC in colitic mice may reflect defective gut tolerogenic conditioning or altered migratory pathways and raise the possibility that migratory DC populations contribute to the pathogenesis of inflammatory bowel disease. |
