Primary Identifier | MGI:1919737 | Organism | mouse, laboratory |
Chromosome | 1 | NCBI Gene Number | 108909 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables protein domain specific binding activity. Involved in negative regulation of JNK cascade and negative regulation of protein-containing complex assembly. Acts upstream of or within negative regulation of JUN kinase activity and regulation of protein-containing complex assembly. Located in cytoplasm. Orthologous to human AIDA (axin interactor, dorsalization associated). PHENOTYPE: Homozygous knockout leads to increased lipid absorption and fat deposits, resulting in severe obesity, hypertriglyceridemia, hyperglycemia and hyperinsulinemia. [provided by MGI curators] |