| First Author | Milton S | Year | 1992 |
| Journal | Endocrinology | Volume | 131 |
| Issue | 1 | Pages | 536-8 |
| PubMed ID | 1612034 | Mgi Jnum | J:129438 |
| Mgi Id | MGI:3769275 | Doi | 10.1210/endo.131.1.1612034 |
| Citation | Milton S, et al. (1992) Transgenic female mice with high human growth hormone levels are fertile and capable of normal lactation without having been pregnant. Endocrinology 131(1):536-8 |
| abstractText | Transgenic mice carrying the phosphoenolpyruvate carboxykinase promoter region-human growth hormone (PEPCK-hGH) fusion gene are characterized by accelerated growth and plasma hGH levels ranging from 100 to 700 ng/ml. Both sexes are fertile, in contrast to previous findings in metallothionein-I/hGH transgenic mice in which females are sterile, apparently due to luteal failure. Virgin transgenic PEPCK/hGH females from this line produce milk and can successfully raise foster litters to weaning. We conclude that the life-long presence of very large amounts of hGH in the circulation is compatible with ovulation, can override the effects of hGH-induced suppression of endogenous PRL release, and can support full lactation in animals that have not been primed by hormonal changes associated with pregnancy. |
